NutriStack
Coenzyme Q10 and Propranolol, a synergy.
Propranolol is the strongest CoQ10-enzyme inhibitor among beta-blockers, which contributes to fatigue and exercise intolerance. CoQ10 supplementation restores mitochondrial enzyme activity and may help offset these side effects, with the bonus of modest blood-pressure lowering.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Coenzyme Q10 and Propranolol
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Propranolol is the strongest CoQ10-enzyme inhibitor among beta-blockers, which contributes to fatigue and exercise intolerance. CoQ10 supplementation restores mitochondrial enzyme activity and may help offset these side effects, with the bonus of modest blood-pressure lowering.
Mechanism. Propranolol potently inhibits NADH-oxidase and succinate-oxidase activity in mitochondria, depleting functional CoQ10. Supplementation restores enzyme activity and ATP synthesis in cardiac and skeletal muscle.
Recommendation. Consider CoQ10 100-200 mg/day with food if you experience fatigue, exercise intolerance, or muscle aches on propranolol. Monitor blood pressure since CoQ10 may produce a small additional drop.
Sources (2)
- Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Res Commun Chem Pathol Pharmacol. 1977;17(1):157-64. PMID 17892
- Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007;21(4):297-306. PMID 17287847
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 and Propranolol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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