NutriStack
Melatonin and Propranolol, a synergy.
Propranolol suppresses nocturnal melatonin synthesis by blocking pineal beta-1 receptors. Melatonin supplementation can restore sleep quality in propranolol-treated patients.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Melatonin and Propranolol
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Propranolol suppresses nocturnal melatonin synthesis by blocking pineal beta-1 receptors. Melatonin supplementation can restore sleep quality in propranolol-treated patients.
Mechanism. Propranolol blocks both beta-1 and beta-2 receptors, including pineal beta-1 receptors that trigger melatonin synthesis via AANAT. Non-selective beta-blockers suppress melatonin more than selective ones.
Recommendation. Melatonin 0.5-3mg at bedtime may help with propranolol-induced insomnia. This is a well-documented effect of non-selective beta-blockers.
Sources (4)
- Stoschitzky K et al. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol. 1999;55(2):111-115. PMID 10335905
- Fatemeh G, Sajjad M, Niloufar R et al.. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.. Journal of Neurology. 2022. PMID 33417003
- Tang BHY, Manalo J, Chowdhury SR et al.. Melatonin Use in the ICU: A Systematic Review and Meta-Analysis.. Critical Care Medicine. 2025. PMID 40662882
- Chan V, Lo K. Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis.. Postgraduate Medical Journal. 2022. PMID 33441476
Stack Score
How this pair moves the number.
Effect on the composite score
If both Melatonin and Propranolol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.