NutriStack
Green Tea Extract and Propranolol, a caution.
Green tea extract contains caffeine, which propranolol blunts the cardiovascular response to, and vice versa. High-dose green tea extract can also modestly raise blood pressure acutely from caffeine while EGCG produces opposite chronic vasodilatory effects, giving an unpredictable net effect when stacked with propranolol.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Green Tea Extract and Propranolol
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Green tea extract contains caffeine, which propranolol blunts the cardiovascular response to, and vice versa. High-dose green tea extract can also modestly raise blood pressure acutely from caffeine while EGCG produces opposite chronic vasodilatory effects, giving an unpredictable net effect when stacked with propranolol.
Mechanism. Caffeine in green tea is a non-selective adenosine receptor antagonist that produces transient blood pressure rises blunted by beta blockade. EGCG and other catechins have separate effects on endothelial function and lipid absorption that complicate the net hemodynamic response.
Recommendation. Limit high-dose green tea extract supplements while on propranolol; modest dietary green tea is usually fine. If you take a concentrated extract, monitor blood pressure and heart rate when starting.
Sources (2)
- Smits P, Hoffmann H, Thien T, Houben H, van't Laar A. Hemodynamic and humoral effects of coffee after beta 1-selective and nonselective beta-blockade. Clin Pharmacol Ther. 1983;34(2):153-8. PMID 6347498
- Belza A, Toubro S, Stender S, Astrup A. Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects. Int J Obes (Lond). 2009;33(4):456-64. (caffeine/thermogenesis interaction) PMID 19497591
Stack Score
How this pair moves the number.
Effect on the composite score
If both Green Tea Extract and Propranolol are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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