NutriStack
Combined Oral Contraceptive and Vitamin B2, a synergy.
Combined oral contraceptives modestly lower riboflavin (B2) status by altering hepatic enzyme turnover and erythrocyte glutathione reductase activity. The effect is small in well-nourished women but can be relevant for those with limited dietary intake.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Combined Oral Contraceptive and Vitamin B2
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Combined oral contraceptives modestly lower riboflavin (B2) status by altering hepatic enzyme turnover and erythrocyte glutathione reductase activity. The effect is small in well-nourished women but can be relevant for those with limited dietary intake.
Mechanism. Estrogens increase the hepatic synthesis of flavoproteins and accelerate riboflavin catabolism, reducing the pool of flavin mononucleotide and flavin adenine dinucleotide cofactors.
Recommendation. A daily multivitamin or B-complex supplement providing 1.3-2 mg of riboflavin is sufficient for women on combined oral contraception. Take with food.
Sources (2)
- Palmery M, Saraceno A, Vaiarelli A, Carlomagno G. Oral contraceptives and changes in nutritional requirements. Eur Rev Med Pharmacol Sci. 2013;17(13):1804-13. PMID 23852908
- Basciani S, Porcaro G. Counteracting side effects of combined oral contraceptives through the administration of specific micronutrients. Eur Rev Med Pharmacol Sci. 2022;26(13):4846-4862. PMID 35856377
Stack Score
How this pair moves the number.
Effect on the composite score
If both Combined Oral Contraceptive and Vitamin B2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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