NutriStack
Methylfolate and Vitamin B2, a synergy.
Riboflavin is the cofactor for the MTHFR enzyme that converts folate to its active form, so good riboflavin status improves folate-mediated lowering of homocysteine, especially in people with the MTHFR 677 TT genotype.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Methylfolate and Vitamin B2
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Riboflavin is the cofactor for the MTHFR enzyme that converts folate to its active form, so good riboflavin status improves folate-mediated lowering of homocysteine, especially in people with the MTHFR 677 TT genotype.
Mechanism. MTHFR uses riboflavin-derived FAD as its cofactor; in the thermolabile TT variant the enzyme loses FAD more readily, so optimizing riboflavin stabilizes MTHFR activity and supports folate-driven remethylation of homocysteine to methionine.
Recommendation. Ensure adequate riboflavin when using methylfolate to lower homocysteine, particularly for MTHFR 677 TT individuals in whom riboflavin status strongly modulates the response.
Sources (2)
- McNulty H et al. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C to T polymorphism. Circulation. 2006
- McNulty H et al. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR C677T genotype. Clinical Chemistry. 2003
Stack Score
How this pair moves the number.
Effect on the composite score
If both Methylfolate and Vitamin B2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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