NutriStack
Iron and Vitamin B2, a synergy.
Riboflavin supports mobilization of stored iron and red blood cell production, so correcting riboflavin status can improve the hematologic response to iron supplementation in deficiency.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Iron and Vitamin B2
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Riboflavin supports mobilization of stored iron and red blood cell production, so correcting riboflavin status can improve the hematologic response to iron supplementation in deficiency.
Mechanism. Riboflavin-derived flavin coenzymes support release of iron from ferritin and gut handling of iron, as well as flavin-dependent steps in erythropoiesis, so deficiency impairs iron mobilization and hemoglobin synthesis.
Recommendation. Ensure adequate riboflavin intake when treating iron-deficiency anemia, since riboflavin deficiency can blunt the rise in hemoglobin despite iron therapy.
Sources (2)
- Powers HJ. Riboflavin (vitamin B-2) and health. American Journal of Clinical Nutrition. 2003
- Powers HJ et al. The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia. British Journal of Nutrition. 1983
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iron and Vitamin B2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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