NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Iron and Vitamin B2: what the published research says

PubMed indexes 4 records that name Iron and Vitamin B2 together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Iron and Vitamin B2. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Iron and Vitamin B2.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia.

bioRxiv : the preprint server for biology · 2025 · PMID 40666848

Preprint

“We identify a window of therapeutic opportunity upon riboflavin starvation or chemical riboflavin metabolism perturbation and demonstrate that this strongly synergizes with BCL-2 inhibition. Our work identifies riboflavin as a critical metabolic dependency in leukemia, with functions beyond energy production.”

Bjelosevic et al. · From the abstract

Names both Iron and Vitamin B2 in its title.

Overview on the Bacterial Iron-Riboflavin Metabolic Axis.

Frontiers in microbiology · 2018 · PMID 30026736

Review

“In addition, riboflavin is involved in dissimilatory iron reduction during extracellular respiration by some species. The main direct metabolic relationships between riboflavin and iron in bacterial physiology are reviewed here.”

SepĂșlveda Cisternas et al. · From the abstract

Names both Iron and Vitamin B2 in its title.

Association between irritable bowel syndrome and micronutrients: A systematic review.

Journal of gastroenterology and hepatology · 2022 · PMID 35581170

Systematic ReviewHuman subjects

“Irritable bowel syndrome patients are at risk of developing multiple micronutrient deficiencies that may have both localized gastrointestinal as well as systemic effects. Dietary management of IBS patients should include a proper dietitian review to ensure nutritional adequacy where possible.”

Bek et al. · Authors' conclusion

Names Iron and Vitamin B2 together in an interaction, co-administration, or pharmacokinetic context.

The role of vitamins in the prevention and control of anaemia.

Public health nutrition · 2000 · PMID 10948381

Systematic ReviewHuman subjects

“In general, the public health impact of vitamin supplementation in controlling anaemia is not clear. Neither are the complex interactions involving multiple vitamins in haematopoiesis sufficiently understood to explain the observed variability in haematological responses to vitamins by age, population, vitamin mixture and dosages.”

Fishman et al. · Authors' conclusion

Names Iron and Vitamin B2 together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Iron, Vitamin B2, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.