NutriStack
Vitamin B2 and Vitamin B3, a synergy.
B2 (riboflavin) is needed for the synthesis of NAD+ from niacin (B3) via the kynurenine pathway.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin B2 and Vitamin B3
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. B2 (riboflavin) is needed for the synthesis of NAD+ from niacin (B3) via the kynurenine pathway.
Mechanism. FAD (from riboflavin) is a cofactor for kynurenine 3-monooxygenase in the de novo NAD+ synthesis pathway from tryptophan/niacin.
Recommendation. Taking B-complex ensures adequate co-factor support for all B vitamin interconversions.
Sources (1)
- Sauve AA. NAD+ and vitamin B3. J Pharmacol Exp Ther. 2008
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin B2 and Vitamin B3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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