NutriStack
Diclofenac and Garlic Extract, a caution.
Concentrated garlic extract may increase bleeding tendency when combined with diclofenac. Diclofenac can injure the GI lining, while garlic supplements may affect platelet aggregation. The risk is most relevant with regular diclofenac use, high-dose garlic extract, ulcer history, or other bleeding-risk medicines.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
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At a glance
- Substances
- Diclofenac and Garlic Extract
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Concentrated garlic extract may increase bleeding tendency when combined with diclofenac. Diclofenac can injure the GI lining, while garlic supplements may affect platelet aggregation. The risk is most relevant with regular diclofenac use, high-dose garlic extract, ulcer history, or other bleeding-risk medicines.
Mechanism. Garlic preparations can alter platelet aggregation and bleeding time in human studies. Diclofenac reduces prostaglandin-mediated gastric protection through COX inhibition, creating a setting where platelet effects may worsen bleeding.
Recommendation. Avoid high-dose garlic extract while using diclofenac regularly. If both are used, watch for bruising, nosebleeds, black stools, vomiting blood, or worsening stomach pain.
Sources (2)
- Fakhar H, Hashemi Tayer A. Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time. Iran J Ped Hematol Oncol. 2012;2(4):146-152. PMID 24575255
- Castellsague J, Riera-Guardia N, Calingaert B, Varas-Lorenzo C, Fourrier-Reglat A, Nicotra F, et al. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012;35(12):1127-1146. PMID 23137151
Stack Score
How this pair moves the number.
Effect on the composite score
If both Diclofenac and Garlic Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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