NutriStack
Dofetilide and Magnesium Glycinate, a synergy.
Dofetilide can cause torsades de pointes, and low magnesium is a recognized risk factor. Maintaining normal magnesium helps reduce susceptibility to early afterdepolarizations and supports potassium repletion. Oral magnesium can help prevent or correct low magnesium, but acute torsades requires emergency management.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
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At a glance
- Substances
- Dofetilide and Magnesium Glycinate
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Dofetilide can cause torsades de pointes, and low magnesium is a recognized risk factor. Maintaining normal magnesium helps reduce susceptibility to early afterdepolarizations and supports potassium repletion. Oral magnesium can help prevent or correct low magnesium, but acute torsades requires emergency management.
Mechanism. Dofetilide blocks IKr and prolongs repolarization. Hypomagnesemia promotes electrical instability and early afterdepolarizations; magnesium repletion is part of standard torsades prevention and treatment.
Recommendation. Maintain adequate magnesium intake and ask about magnesium checks if you take diuretics, PPIs, or have gastrointestinal losses. Do not use high-dose magnesium without monitoring if you have kidney disease, and seek urgent care for fainting, near-fainting, or new sustained palpitations.
Sources (2)
- Jaiswal A, Goldbarg S. Dofetilide induced torsade de pointes: mechanism, risk factors and management strategies. Indian Heart J. 2014;66(6):640-648. PMID 25634399
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139-152. PMID 27212965
Stack Score
How this pair moves the number.
Effect on the composite score
If both Dofetilide and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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