NutriStack
Doxycycline and Magnesium Glycinate, timing-sensitive.
Magnesium chelates doxycycline, reducing its absorption and potentially compromising treatment efficacy. Magnesium-containing antacids are well-known to impair tetracycline absorption. The interaction is clinically significant and requires proper dose spacing.
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At a glance
- Substances
- Doxycycline and Magnesium Glycinate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Magnesium chelates doxycycline, reducing its absorption and potentially compromising treatment efficacy. Magnesium-containing antacids are well-known to impair tetracycline absorption. The interaction is clinically significant and requires proper dose spacing.
Mechanism. Magnesium divalent cations chelate doxycycline via its multiple hydroxyl and keto groups, forming poorly soluble magnesium-tetracycline complexes that resist intestinal absorption.
Recommendation. Separate doxycycline and magnesium supplements by at least 2 hours. This includes magnesium-containing antacids and laxatives. Take doxycycline with water on an empty stomach when possible.
Minimum separation. 120
Sources (4)
- Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs. 1976;11(1):45-54. PMID 1083209
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Doxycycline and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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