What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Ergothioneine + Green Tea Extract pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Insufficient evidence

Ergothioneine + Green Tea Extract

Q: Can I take Ergothioneine and Green Tea Extract together?

Yes. The combination of Ergothioneine and Green Tea Extract produces a measurable benefit. Green tea catechins and ergothioneine are both dietary antioxidants with anti-inflammatory activity that can act through complementary mechanisms.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Insufficient evidence

Green tea catechins and ergothioneine are both dietary antioxidants with anti-inflammatory activity that can act through complementary mechanisms.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Ergothioneine and Green Tea Extract

Pair type

Synergy

Evidence

Insufficient

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyInsufficient evidence

What is happening. Green tea catechins and ergothioneine are both dietary antioxidants with anti-inflammatory activity that can act through complementary mechanisms.

Mechanism. Ergothioneine provides transporter-mediated intracellular antioxidant defense; green tea polyphenols scavenge free radicals and modulate redox signaling. Effects are additive rather than competitive.

Recommendation. Generally compatible. Be mindful of total catechin (EGCG) load from concentrated green tea extracts, which carries its own hepatotoxicity caution at high doses, independent of ergothioneine.

Stack Score

How it moves the number.

Effect on the composite score

If both Ergothioneine and Green Tea Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Halliwell B, Cheah IK, Tang RMY. Ergothioneine - a diet-derived antioxidant with therapeutic potential. FEBS Letters. 2018.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index