What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Ergothioneine + Vitamin C pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Emerging evidence

Ergothioneine + Vitamin C

Q: Can I take Ergothioneine and Vitamin C together?

Yes. The combination of Ergothioneine and Vitamin C produces a measurable benefit. Vitamin C is an aqueous-phase antioxidant and can help regenerate other antioxidants, while ergothioneine provides stable intracellular and mitochondrial protection. The combination broadens antioxidant coverage across cellular compartments.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Emerging evidence

Vitamin C is an aqueous-phase antioxidant and can help regenerate other antioxidants, while ergothioneine provides stable intracellular and mitochondrial protection. The combination broadens antioxidant coverage across cellular compartments.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Ergothioneine and Vitamin C

Pair type

Synergy

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyEmerging evidence

What is happening. Vitamin C is an aqueous-phase antioxidant and can help regenerate other antioxidants, while ergothioneine provides stable intracellular and mitochondrial protection. The combination broadens antioxidant coverage across cellular compartments.

Mechanism. Ergothioneine and ascorbate both neutralize reactive oxygen species and can participate in interlinked antioxidant recycling networks, acting in different cellular phases.

Recommendation. Safe to take together; no separation required. View any benefit as supportive rather than proven.

Stack Score

How it moves the number.

Effect on the composite score

If both Ergothioneine and Vitamin C are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Cheah IK, Halliwell B. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochimica et Biophysica Acta. 2012.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index