What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Fenugreek + Glipizide pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Fenugreek and Glipizide, a caution.

Q: Can I take Fenugreek and Glipizide together?

Possibly, but with caution. Fenugreek and Glipizide have a documented caution-tier interaction. Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Stacked on glipizide, which already forces pancreatic insulin secretion, the additive glucose-lowering can produce symptomatic hypoglycemia. The risk is higher in older adults, after missed meals, or in patients with reduced kidney function.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Stacked on glipizide, which already forces pancreatic insulin secretion, the additive glucose-lowering can produce symptomatic hypoglycemia. The risk is higher in older adults, after missed meals, or in patients with reduced kidney function.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Fenugreek and Glipizide
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Stacked on glipizide, which already forces pancreatic insulin secretion, the additive glucose-lowering can produce symptomatic hypoglycemia. The risk is higher in older adults, after missed meals, or in patients with reduced kidney function.

Mechanism. Fenugreek's 4-hydroxyisoleucine stimulates glucose-dependent insulin release, and its soluble galactomannan fiber slows carbohydrate absorption. Glipizide forces pancreatic insulin secretion by closing K-ATP channels. The two mechanisms are additive.

Recommendation. Do not start fenugreek on glipizide without telling your prescriber. Check fingerstick glucose more often (before meals and at bedtime) for the first 2-4 weeks and ask whether the glipizide dose should be reduced.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Fenugreek and Glipizide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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