Interaction databaseSupplement × SupplementReviewed May 2026

Fenugreek and Tribulus Terrestris, a synergy.

Tribulus and fenugreek are both used in male vitality and libido formulas, with complementary effects on sexual function and, for fenugreek, some evidence for supporting free testosterone.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Fenugreek and Tribulus Terrestris
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
2 sources
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Tribulus and fenugreek are both used in male vitality and libido formulas, with complementary effects on sexual function and, for fenugreek, some evidence for supporting free testosterone.

Mechanism. Tribulus saponins support libido and nitric oxide pathways while fenugreek furostanol saponins may inhibit aromatase and 5-alpha-reductase, together influencing androgen activity and sexual function.

Recommendation. Reasonable combination for libido and vitality goals. Monitor blood glucose because fenugreek can lower it, especially if on antidiabetic medication.

Sources (2)
  1. Neychev V, Mitev V, Pro-sexual and androgen enhancing effects of Tribulus terrestris, Journal of Ethnopharmacology, 2016
  2. Wankhede S et al, Examining the effect of fenugreek extract on hormonal profile in male subjects, Journal of Sport and Health Science, 2016

Stack Score

How this pair moves the number.

Effect on the composite score

If both Fenugreek and Tribulus Terrestris are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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