Can I take Fish Oil and Vortioxetine together?

Possibly, but with caution. Fish Oil and Vortioxetine have a documented caution-tier interaction. Vortioxetine may increase bleeding tendency through serotonin effects on platelets. High-dose fish oil can have mild antiplatelet effects.

What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Fish Oil + Vortioxetine pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Emerging evidence

Fish Oil + Vortioxetine

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Vortioxetine may increase bleeding tendency through serotonin effects on platelets. High-dose fish oil can have mild antiplatelet effects.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Fish Oil and Vortioxetine

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Vortioxetine may increase bleeding tendency through serotonin effects on platelets. High-dose fish oil can have mild antiplatelet effects.

Mechanism. Serotonergic antidepressants impair platelet serotonin uptake; omega-3 fatty acids can modestly reduce platelet aggregation.

Recommendation. Use usual dietary or standard supplemental fish oil cautiously; monitor for bruising or bleeding, especially with anticoagulants, antiplatelet drugs, NSAIDs, surgery, or bleeding disorders.

Stack Score

How it moves the number.

Effect on the composite score

If both Fish Oil and Vortioxetine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Takeda Pharmaceuticals America Inc. TRINTELLIX US Prescribing Information. 2026.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index