Supplement × Prescription·contraindicated·Moderate evidence
St. John's Wort has serotonergic activity and can interact unpredictably with antidepressants.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort has serotonergic activity and can interact unpredictably with antidepressants.
Mechanism. Serotonergic effects can be additive, increasing risk of serotonin syndrome; enzyme induction may also alter exposure to other medications.
Recommendation. Do not combine St. John's Wort with vortioxetine; involve the prescriber before starting or stopping either agent.
Effect on the composite score
If both St. John's Wort and Vortioxetine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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