Supplement × Prescription·contraindicated·Moderate evidence
Supplemental L-Tryptophan can increase serotonin synthesis and raise serotonin-toxicity risk with vortioxetine.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Supplemental L-Tryptophan can increase serotonin synthesis and raise serotonin-toxicity risk with vortioxetine.
Mechanism. Tryptophan is converted to 5-HTP and then serotonin, adding to vortioxetine-related serotonergic tone.
Recommendation. Avoid concentrated L-Tryptophan supplements during vortioxetine therapy; normal dietary protein is not the concern.
Effect on the composite score
If both L-Tryptophan and Vortioxetine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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