What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Fluvoxamine + Green Tea Extract pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Fluvoxamine and Green Tea Extract, a caution.

Q: Can I take Fluvoxamine and Green Tea Extract together?

Possibly, but with caution. Fluvoxamine and Green Tea Extract have a documented caution-tier interaction. Fluvoxamine is a potent CYP1A2 inhibitor, and the caffeine in green tea extracts is metabolized almost entirely by CYP1A2. In healthy volunteers, fluvoxamine reduced caffeine clearance about five-fold and extended caffeine half-life from roughly 5 hours to 31 hours. Even low caffeine intake from a green tea supplement can produce jitteriness, palpitations, insomnia, and anxiety the next day.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Fluvoxamine is a potent CYP1A2 inhibitor, and the caffeine in green tea extracts is metabolized almost entirely by CYP1A2. In healthy volunteers, fluvoxamine reduced caffeine clearance about five-fold and extended caffeine half-life from roughly 5 hours to 31 hours. Even low caffeine intake from a green tea supplement can produce jitteriness, palpitations, insomnia, and anxiety the next day.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Fluvoxamine and Green Tea Extract
Pair type: Caution
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Strong evidence

Caution

What is happening. Fluvoxamine is a potent CYP1A2 inhibitor, and the caffeine in green tea extracts is metabolized almost entirely by CYP1A2. In healthy volunteers, fluvoxamine reduced caffeine clearance about five-fold and extended caffeine half-life from roughly 5 hours to 31 hours. Even low caffeine intake from a green tea supplement can produce jitteriness, palpitations, insomnia, and anxiety the next day.

Mechanism. Fluvoxamine inhibits hepatic CYP1A2, the primary metabolic enzyme for caffeine. Inhibition reduces caffeine clearance by about 80% and prolongs its half-life roughly six-fold, leading to caffeine accumulation.

Recommendation. Avoid caffeine-containing green tea extracts while on fluvoxamine. Decaffeinated green tea extract is the safer option. If you do drink green tea, keep intake low and avoid afternoon use to prevent insomnia from prolonged caffeine half-life.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Fluvoxamine and Green Tea Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index