NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Fluvoxamine

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Prescription selective serotonin reuptake inhibitor (SSRI) primarily approved for the treatment of obsessive-compulsive disorder (OCD) in adults and children aged 8 and older. Also used off-label for social anxiety disorder and depression. Notable for its sigma-1 receptor agonism, which may contribute to anti-inflammatory and neuroprotective effects. Dosage must be determined by your prescribing physician.

Evidence tier
Strong
Indexed sources
10 1994–2025
Interactions
0
Depletes
2 nutrients
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Prescription selective serotonin reuptake inhibitor (SSRI) primarily approved for the treatment of obsessive-compulsive disorder (OCD) in adults and children aged 8 and older. NutriStack rates the supporting evidence as strong. Common adult dosing is 50–300 mg daily (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete sodium, folate. This profile indexes 10 sources.

What it's good for
  • OCD symptom reduction
  • Anxiety reduction5
  • Compulsive behavior reduction9
  • Social anxiety improvement5
What to watch for
  • Nausea
  • Insomnia
  • Drowsiness
  • Concurrent MAOI use (within 14 days)
  • Concurrent tizanidine, thioridazine, alosetron, or pimozide use

The bottom line

Evidence rating strong. Most-documented uses: ocd symptom reduction, anxiety reduction, compulsive behavior reduction. 10 sources indexed (1994–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Selectively inhibits the reuptake of serotonin (5-HT) by blocking SERT. Also acts as a sigma-1 receptor agonist, which may modulate glutamate signaling and inflammatory pathways. Potent CYP1A2 and CYP2C19 inhibitor, leading to clinically significant drug interactions.9

Class
SSRI
Dosing

Dosing & protocol.

Common range
50–300 mg daily (as prescribed by your physician)
Recommended form
Tablet or extended-release capsule

Can be taken with or without food. Higher doses are typically divided into two daily doses. Extended-release capsules should be swallowed whole.

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

Sodium

Significant

SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy.

Monitor Serum sodiumOnset Most often within the first 2-12 weeks

Folate

Mild

Lower folate status is associated with poorer SSRI response and may be reduced in some chronic users through altered one-carbon metabolism.

Replace MethylfolateMonitor Serum folate or RBC folateOnset Usually over months

Full Fluvoxamine depletion and interaction guide →

Safety

Full safety detail.

Side effects

  • Nausea
  • Insomnia
  • Drowsiness
  • Dizziness
  • Headache
  • Dry mouth
  • Sexual dysfunction

Contraindications

  • Concurrent MAOI use (within 14 days)
  • Concurrent tizanidine, thioridazine, alosetron, or pimozide use
  • Known hypersensitivity to fluvoxamine1,2
  • Concurrent ramelteon use
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

6

Reviews & position papers

1

Reference material

3
FAQ

Common questions.

Quick answers about Fluvoxamine, drawn from the data on this page.

What is Fluvoxamine?

Prescription selective serotonin reuptake inhibitor (SSRI) primarily approved for the treatment of obsessive-compulsive disorder (OCD) in adults and children aged 8 and older. Also used off-label for social anxiety disorder and depression. Notable for its sigma-1 receptor agonism, which may contribute to anti-inflammatory and neuroprotective effects. Dosage must be determined by your prescribing physician.

What is Fluvoxamine used for?

Commonly cited benefits of Fluvoxamine include: OCD symptom reduction; Anxiety reduction; Compulsive behavior reduction; Social anxiety improvement. NutriStack rates the overall evidence as strong.

What is a typical dose of Fluvoxamine?

A typical adult dose of Fluvoxamine is 50–300 mg daily (as prescribed by your physician). The commonly recommended form is Tablet or extended-release capsule. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Fluvoxamine?

Reported side effects include nausea, insomnia, drowsiness, dizziness, headache, dry mouth. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Fluvoxamine?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Fluvoxamine in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.