What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Fosfomycin + Zinc pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Emerging evidence

Fosfomycin + Zinc

Q: Can I take Fosfomycin and Zinc together?

Yes, if you separate them in time. Fosfomycin and Zinc have a documented timing-sensitive interaction. Zinc is a divalent cation that, like other metal cations, can chelate fosfomycin in the gut and reduce its absorption. This may lower the urinary antibiotic concentration required to clear an uncomplicated urinary tract infection with a single dose.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Emerging evidence

Zinc is a divalent cation that, like other metal cations, can chelate fosfomycin in the gut and reduce its absorption. This may lower the urinary antibiotic concentration required to clear an uncomplicated urinary tract infection with a single dose.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Fosfomycin and Zinc

Pair type

Timing Sensitive

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveEmerging evidence

What is happening. Zinc is a divalent cation that, like other metal cations, can chelate fosfomycin in the gut and reduce its absorption. This may lower the urinary antibiotic concentration required to clear an uncomplicated urinary tract infection with a single dose.

Mechanism. Divalent cation (zinc) chelation of fosfomycin in the gastrointestinal tract forms a poorly absorbed complex, decreasing oral bioavailability.

Recommendation. Avoid taking zinc supplements at the same time as the single fosfomycin dose. Take the antibiotic separately and resume zinc a few hours later or the next day.

Stack Score

How it moves the number.

Effect on the composite score

If both Fosfomycin and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Fosfomycin tromethamine (Monurol) U.S. prescribing information. Coadministration with divalent and polyvalent cation-containing products lowers fosfomycin serum and urinary concentrations.Needs sourceNo link

Check your full routine

One pair was the worked example.

Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.

Open the interaction checker → Browse the research index