What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Garlic Extract + Naproxen pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Garlic Extract and Naproxen, a caution.

Q: Can I take Garlic Extract and Naproxen together?

Possibly, but with caution. Garlic Extract and Naproxen have a documented caution-tier interaction. Concentrated garlic extract may add antiplatelet effects to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper GI complications, so even modest platelet effects may matter in high-risk people. The concern is highest with supplement-dose garlic extract, prior ulcers, older age, or other blood thinners.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Concentrated garlic extract may add antiplatelet effects to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper GI complications, so even modest platelet effects may matter in high-risk people. The concern is highest with supplement-dose garlic extract, prior ulcers, older age, or other blood thinners.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Garlic Extract and Naproxen
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Concentrated garlic extract may add antiplatelet effects to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper GI complications, so even modest platelet effects may matter in high-risk people. The concern is highest with supplement-dose garlic extract, prior ulcers, older age, or other blood thinners.

Mechanism. Garlic constituents can affect platelet aggregation and bleeding time. Naproxen inhibits COX enzymes and reduces protective gastric prostaglandins, increasing the chance that platelet effects translate into clinically relevant bleeding.

Recommendation. Avoid high-dose garlic extract if you take naproxen regularly. Use naproxen at the lowest effective dose and seek care for black stools, vomiting blood, or unusual bruising.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Garlic Extract and Naproxen are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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