NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Naproxen: what the published research says

PubMed indexes 5 records that name Alcohol and Naproxen together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Naproxen. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

5 studies naming Alcohol and Naproxen.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Naproxen-induced methemoglobinemia in an alcohol-dependent patient.

The American journal of emergency medicine · 2014 · PMID 24856747

Case ReportsHuman subjects

“After 10 days in the hospital, the patient was discharged without any complications.Naproxen is known to cause oxidative stress. Alcohol is known to reduce G6PD activity, and thus it is hypothesized that the administration of naproxen in an alcohol-dependent patient caused methemoglobinemia.”

Lee et al. · From the abstract

Names both Alcohol and Naproxen in its title.

Macro- and Nanoscale Effect of Ethanol on Bovine Serum Albumin Gelation and Naproxen Release.

International journal of molecular sciences · 2022 · PMID 35806356

“It was found that the alteration of initial drug loading percentage, hydrogel incubation time as well as BSA and alcohol concentrations affect and thus tune the release rate of SL-NPX from BSA hydrogels. These results lead to the conclusion that BSA hydrogels as controlled release systems offer a remarkable fine-tuning capability for pharmaceutical applications due to the variety of gelation parameters.”

Sanaeifar et al. · From the abstract

Names both Alcohol and Naproxen in its title.

In-Silico Screening of Lipid-Based Drug Delivery Systems.

Pharmaceutical research · 2020 · PMID 33230602

Comparative Study

“The API solubility individually depends on the choice of excipients. The proposed in-silico-screening approach allows formulators to quickly determine most-appropriate types of lipid-based formulations for a given API with low experimental effort. Graphical abstract.”

Brinkmann et al. · Authors' conclusion

Names Alcohol and Naproxen together in an interaction, co-administration, or pharmacokinetic context.

Pharmacokinetic Interactions Between Pelubiprofen and Eperisone Hydrochloride: A Randomized, Open-label, Crossover Study of Healthy Korean Men.

Clinical therapeutics · 2017 · PMID 27989618

Randomized Controlled Trial24 participants

“None of the study participants experienced serious adverse events during the study. No clinically significant changes were noted in the pharmacokinetic interactions of pelubiprofen, the major active metabolite of pelubiprofen (trans-alcohol pelubiprofen), and eperisone hydrochloride between monotherapy and combination therapy with 45-mg sustained-release pelubiprofen and 75-mg sustained-release eperisone hydrochloride.”

Ryu et al. · From the abstract

Names Alcohol and Naproxen together in an interaction, co-administration, or pharmacokinetic context.

The therapeutic efficacy of misoprostol in peptic ulcer disease.

Postgraduate medical journal · 1988 · PMID 3138682

Clinical TrialReview

“Misoprostol is, therefore, a safe and effective drug in the treatment of chronic peptic ulcer and could have a beneficial action in duodenal ulcers refractory to treatment with H2-receptor antagonists. It could benefit compromised groups of ulcer patients who are smokers or alcohol users amd certainly has been shown to protect the gastroduodenal mucosa against damage induced by NSAIDs in healthy volunteers and arthritic patients.”

Watkinson et al. · From the abstract

Names Alcohol and Naproxen together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Naproxen, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.