NutriStack
Garlic Extract and Nattokinase, a caution.
Garlic has antiplatelet activity and nattokinase has fibrinolytic activity, so combining them can additively impair clotting and raise bleeding risk, especially around surgery or with blood thinners.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Garlic Extract and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Garlic has antiplatelet activity and nattokinase has fibrinolytic activity, so combining them can additively impair clotting and raise bleeding risk, especially around surgery or with blood thinners.
Mechanism. Garlic organosulfur compounds inhibit platelet aggregation, while nattokinase degrades fibrin and may enhance endogenous fibrinolysis; acting at different points of hemostasis, the two effects can be additive.
Recommendation. Use together cautiously and monitor for easy bruising, nosebleeds, or prolonged bleeding. Stop both at least 7 to 10 days before surgery and avoid combining with anticoagulant or antiplatelet drugs without clinician oversight.
Sources (4)
- Rahman K et al. Garlic and cardiovascular disease: a critical review. J Nutr. 2006;136(3 Suppl):736S-740S. PMID 16484553
- Allison GL et al. Aged garlic extract and its constituents inhibit platelet aggregation through multiple mechanisms. J Nutr. 2006;136(3 Suppl):782S-788S. PMID 16484563
- Weng Y et al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3). PMID 28264497
- Kurosawa Y et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
Stack Score
How this pair moves the number.
Effect on the composite score
If both Garlic Extract and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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