NutriStack
Iodine and Iron, a synergy.
Iron deficiency impairs thyroid hormone synthesis because thyroid peroxidase (TPO) is a heme-containing enzyme.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Iron deficiency impairs thyroid hormone synthesis because thyroid peroxidase (TPO) is a heme-containing enzyme.
Mechanism. TPO requires heme iron to catalyze iodide oxidation and organification into thyroglobulin. Iron deficiency reduces TPO activity, impairing T3/T4 synthesis even with adequate iodine.
Recommendation. Address iron deficiency when treating thyroid issues. Iron-deficient individuals may not respond well to iodine supplementation alone.
Sources (1)
- Zimmermann MB, Köhrle J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism. Thyroid. 2002
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iodine and Iron are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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