NutriStack
Ivabradine and Magnesium Glycinate, a caution.
Ivabradine can cause clinically important bradycardia, and torsades de pointes has been reported when interacting QT-risk drugs are added. Low magnesium is a recognized torsades risk factor in bradycardic or QT-prolonged states. Magnesium is useful when deficiency is present or likely; it should not be used to mask symptoms such as fainting or severe dizziness.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Ivabradine and Magnesium Glycinate
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Ivabradine can cause clinically important bradycardia, and torsades de pointes has been reported when interacting QT-risk drugs are added. Low magnesium is a recognized torsades risk factor in bradycardic or QT-prolonged states. Magnesium is useful when deficiency is present or likely; it should not be used to mask symptoms such as fainting or severe dizziness.
Mechanism. Ivabradine slows sinus-node firing through If current inhibition, and bradycardia can increase pause-dependent torsades vulnerability. Hypomagnesemia promotes early afterdepolarizations and may impair potassium correction, compounding the electrophysiologic risk.
Recommendation. Maintain normal magnesium intake while taking ivabradine, and ask about checking magnesium if you also use diuretics, proton pump inhibitors, or have chronic diarrhea. Avoid high-dose magnesium without monitoring if you have kidney disease. Seek urgent care for fainting, near-fainting, or sustained palpitations.
Sources (2)
- Savelieva I, Camm AJ. If inhibition with ivabradine: electrophysiological effects and safety. Drug Saf. 2008;31(2):95-107. PMID 18217787
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139-152. PMID 27212965
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ivabradine and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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