Supplement × Prescription·a caution·Emerging evidence

Lacosamide + Magnesium Glycinate

Caution Emerging evidence

Usual magnesium doses are not a direct problem, but very high magnesium exposure in renal impairment can worsen weakness or cardiac conduction concerns.

From the database

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Pair type
Caution
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence

What is happening. Usual magnesium doses are not a direct problem, but very high magnesium exposure in renal impairment can worsen weakness or cardiac conduction concerns.

Mechanism. Excess magnesium can depress neuromuscular and cardiac conduction, while lacosamide can prolong PR interval.

Recommendation. Use standard doses only; avoid high-dose magnesium without clinician guidance in renal disease or known AV block.

Stack Score

How it moves the number.

Effect on the composite score

If both Lacosamide and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Lacosamide tablets US Prescribing Information. 2025.Needs sourceNo link

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