NutriStack
CautionEmerging evidence
What is happening. Melatonin can add to lacosamide-related dizziness and somnolence.
Mechanism. Additive CNS sedation.
Recommendation. Use cautiously and monitor alertness and balance.
Supplement × Prescription·a caution·Emerging evidence
Lacosamide + Melatonin
Caution
Emerging evidence
Melatonin can add to lacosamide-related dizziness and somnolence.
From the database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Substances
Lacosamide and Melatonin
Pair type
Caution
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Stack Score
How it moves the number.
Effect on the composite score
If both Lacosamide and Melatonin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Sources
Sources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Lacosamide tablets US Prescribing Information. 2025.Needs sourceNo link
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