NutriStack
Levofloxacin and Magnesium Glycinate, timing-sensitive.
Magnesium glycinate chelates levofloxacin in the gut, dramatically reducing antibiotic absorption. The bioavailability decrease can exceed 40 percent, which may cause treatment failure for serious infections.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Levofloxacin and Magnesium Glycinate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Magnesium glycinate chelates levofloxacin in the gut, dramatically reducing antibiotic absorption. The bioavailability decrease can exceed 40 percent, which may cause treatment failure for serious infections.
Mechanism. Mg2+ from magnesium glycinate chelates the 3-carboxyl and 4-oxo groups on the fluoroquinolone core, blocking absorption.
Recommendation. Take levofloxacin at least 2 hours before or 2 hours after magnesium glycinate. Do not co-administer.
Minimum separation. 120
Sources (2)
- Fish DN, Chow AT. The clinical pharmacokinetics of levofloxacin. Clin Pharmacokinet. 1997;32(2):101-19. PMID 9068926
- Wiesner A, Zagrodzki P, Gawalska A, Paśko P. Together or Apart? Revealing the Impact of Dietary Interventions on Bioavailability of Quinolones: A Systematic Review with Meta-analyses. Clin Pharmacokinet. 2024;63(6):773-818. PMID 38807006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Levofloxacin and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.