What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 5 citation rows for the Levothyroxine + Magnesium Glycinate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Levothyroxine and Magnesium Glycinate, timing-sensitive.

Q: Can I take Levothyroxine and Magnesium Glycinate together?

Yes, if you separate them in time. Levothyroxine and Magnesium Glycinate have a documented timing-sensitive interaction. Magnesium supplements, particularly magnesium oxide and magnesium hydroxide (antacid forms), can reduce levothyroxine absorption by forming chelate complexes or by raising gastric pH. The magnitude of the interaction is less than calcium or iron but still clinically relevant.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Magnesium supplements, particularly magnesium oxide and magnesium hydroxide (antacid forms), can reduce levothyroxine absorption by forming chelate complexes or by raising gastric pH. The magnitude of the interaction is less than calcium or iron but still clinically relevant.

5 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Levothyroxine and Magnesium Glycinate
Pair type: Timing Sensitive
Evidence (highest tier): Moderate
Source citations: 5 sources
Stack Score effect: −5 to your Stack Score (per scored timing-sensitive row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Timing Sensitive · Moderate evidence

Timing Sensitive

What is happening. Magnesium supplements, particularly magnesium oxide and magnesium hydroxide (antacid forms), can reduce levothyroxine absorption by forming chelate complexes or by raising gastric pH. The magnitude of the interaction is less than calcium or iron but still clinically relevant.

Mechanism. Magnesium ions can form chelate complexes with levothyroxine in the GI tract, reducing absorption. Magnesium-containing antacids also raise gastric pH, which can further impair levothyroxine dissolution and absorption.

Recommendation. Separate levothyroxine and magnesium supplements by at least 4 hours. Take levothyroxine in the morning on an empty stomach, and magnesium later in the day or at bedtime.

Minimum separation. 240

Sources (5)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Levothyroxine and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index