NutriStack
Lion's Mane and Phosphatidylserine, a synergy.
The pair supports neuronal structure and signaling, with Lion's Mane stimulating neurotrophic factors and Phosphatidylserine maintaining neuronal membrane integrity and supporting neurotransmitter release.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Lion's Mane and Phosphatidylserine
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. The pair supports neuronal structure and signaling, with Lion's Mane stimulating neurotrophic factors and Phosphatidylserine maintaining neuronal membrane integrity and supporting neurotransmitter release.
Mechanism. Lion's Mane promotes nerve growth factor and neurite outgrowth, while phosphatidylserine is a major inner-leaflet membrane phospholipid that supports neuronal membrane fluidity and vesicular neurotransmitter release, complementing neurotrophic repair.
Recommendation. Reasonable to stack for memory and age-related cognitive support, taken consistently over time. Both can be taken together, ideally with a meal. No timing separation needed.
Sources (2)
- Mori K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research. 2009
- Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lion's Mane and Phosphatidylserine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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