NutriStack
Bacopa Monnieri and Phosphatidylserine, a synergy.
Phosphatidylserine supports neuronal membrane integrity and stress-axis modulation while Bacopa Monnieri enhances cholinergic signaling and synaptic remodeling, giving complementary support for memory and learning.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Bacopa Monnieri and Phosphatidylserine
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Phosphatidylserine supports neuronal membrane integrity and stress-axis modulation while Bacopa Monnieri enhances cholinergic signaling and synaptic remodeling, giving complementary support for memory and learning.
Mechanism. Phosphatidylserine helps maintain membrane fluidity and receptor function and can blunt cortisol responses to stress. Bacopa Monnieri raises acetylcholine availability, exerts antioxidant activity, and promotes dendritic branching and synaptic plasticity, acting on different stages of memory formation than phosphatidylserine.
Recommendation. Combine for cognitive aging or general memory support. A typical pairing is about 100 to 300 mg phosphatidylserine daily with a standardized Bacopa Monnieri extract (around 300 mg providing 50 percent bacosides). Bacopa benefits build over several weeks of consistent daily use.
Sources (2)
- Zanotta D, Puricelli S, Bonoldi G. Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment. Neuropsychiatric Disease and Treatment. 2014
- Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Scholfield CN. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of Ethnopharmacology. 2014
Stack Score
How this pair moves the number.
Effect on the composite score
If both Bacopa Monnieri and Phosphatidylserine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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