NutriStack
Citicoline and Phosphatidylserine, a synergy.
Citicoline supports phospholipid synthesis broadly, including phosphatidylserine. Together they comprehensively support neuronal membrane health.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Citicoline and Phosphatidylserine
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Citicoline supports phospholipid synthesis broadly, including phosphatidylserine. Together they comprehensively support neuronal membrane health.
Mechanism. Citicoline provides cytidine (→ CTP) and choline for CDP-choline pathway phospholipid synthesis. PS is synthesized from PE and PC via base-exchange enzymes. Citicoline increases substrate pool for PS.
Recommendation. Combine for comprehensive brain membrane support, particularly beneficial for cognitive aging.
Sources (1)
- Secades JJ. Citicoline: pharmacological and clinical review. Rev Neurol. 2011
Stack Score
How this pair moves the number.
Effect on the composite score
If both Citicoline and Phosphatidylserine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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