NutriStack
Fish Oil and Phosphatidylserine, a synergy.
Phosphatidylserine is a phospholipid that benefits from omega-3 DHA, which is preferentially incorporated into PS in brain membranes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fish Oil and Phosphatidylserine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Phosphatidylserine is a phospholipid that benefits from omega-3 DHA, which is preferentially incorporated into PS in brain membranes.
Mechanism. DHA from fish oil is incorporated into the sn-2 position of phosphatidylserine in neuronal membranes, enhancing membrane fluidity and PS-dependent signaling (PKC activation, Akt/PI3K).
Recommendation. Take together. DHA-enriched phosphatidylserine may be more effective for cognitive function than soy-derived PS.
Sources (2)
- Kim HY et al. Phosphatidylserine in the brain. Prog Lipid Res. 2014
- Uchida Y, Tsuji K, Ochi E. Effects of Omega-3 fatty acids supplementation and resistance training on skeletal muscle.. Clinical Nutrition ESPEN. 2024. PMID 38777432
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Phosphatidylserine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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