NutriStack
Magnesium Glycinate and Metoprolol, a synergy.
Magnesium acts as a natural calcium channel blocker and can enhance the blood pressure-lowering and heart rate-reducing effects of metoprolol through complementary mechanisms. A double-blind crossover study showed that nutritional-dose magnesium supplementation in hypertensive patients on beta-blockers further lowered systolic blood pressure. While generally beneficial, the additive hypotensive and bradycardic effects require monitoring.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Metoprolol
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 5 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Magnesium acts as a natural calcium channel blocker and can enhance the blood pressure-lowering and heart rate-reducing effects of metoprolol through complementary mechanisms. A double-blind crossover study showed that nutritional-dose magnesium supplementation in hypertensive patients on beta-blockers further lowered systolic blood pressure. While generally beneficial, the additive hypotensive and bradycardic effects require monitoring.
Mechanism. Magnesium reduces intracellular sodium and calcium while increasing intracellular potassium. It functions as a physiological calcium antagonist, relaxing vascular smooth muscle. Combined with metoprolol's beta-1 adrenergic blockade, the dual mechanism produces additive blood pressure and heart rate reduction.
Recommendation. Magnesium supplementation is generally safe and potentially beneficial with metoprolol, but monitor for excessive blood pressure reduction (systolic <100 mmHg) or bradycardia (HR <50 bpm). Start with moderate doses (200-350 mg/day supplemental elemental magnesium) and check blood pressure regularly when initiating.
Sources (5)
- Wirell MP et al. Nutritional dose of magnesium in hypertensive patients on beta blockers lowers systolic blood pressure: a double-blind, cross-over study. J Intern Med. 1994;236(2):189-195. PMID 7913949
- Sontia B, Bhansali A. Magnesium supplementation with metoprolol cardiovascular effects. Improvement of cardiovascular effects of metoprolol by replacement of common salt with a potassium- and magnesium-enriched salt alternative. Br Heart J. 1994;72(1):68-74. PMID 8075882
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Metoprolol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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