Can I take Magnesium Glycinate and Sodium Bicarbonate together?

Yes, if you separate them in time. Magnesium Glycinate and Sodium Bicarbonate have a documented timing-sensitive interaction. Both can cause GI symptoms in some users, especially near training.

What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Magnesium Glycinate + Sodium Bicarbonate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·timing-sensitive·Insufficient evidence

Magnesium Glycinate + Sodium Bicarbonate

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Insufficient evidence

Both can cause GI symptoms in some users, especially near training.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Magnesium Glycinate and Sodium Bicarbonate

Pair type

Timing Sensitive

Evidence

Insufficient

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

Timing SensitiveInsufficient evidence

What is happening. Both can cause GI symptoms in some users, especially near training.

Mechanism. Additive osmotic and GI motility effects.

Recommendation. Separate doses if diarrhea or cramping occurs.

Stack Score

How it moves the number.

Effect on the composite score

If both Magnesium Glycinate and Sodium Bicarbonate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Peart DJ et al. Sodium bicarbonate review. Sports Med. 2012.Needs sourceNo link

Check your full routine

One pair was the worked example.

Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.

Open the interaction checker → Browse the research index