NutriStack
Magnesium Glycinate and Verapamil, a caution.
Both verapamil and magnesium block calcium channels. Combined use can cause excessive bradycardia, hypotension, and AV conduction delay.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Verapamil
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both verapamil and magnesium block calcium channels. Combined use can cause excessive bradycardia, hypotension, and AV conduction delay.
Mechanism. Verapamil blocks L-type calcium channels in cardiac and vascular tissue. Magnesium is a natural calcium antagonist acting on the same channels. Additive negative chronotropic and dromotropic effects can occur.
Recommendation. Use low-dose magnesium (200mg) with verapamil. Monitor heart rate and BP. Avoid if heart rate <55 bpm.
Sources (4)
- Shechter M. Magnesium and cardiovascular system. Magnes Res. 2010;23(2):60-72. PMID 20513641
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Verapamil are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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