NutriStack
Magnesium Glycinate and Vitamin K2, a synergy.
Magnesium supports the vitamin D activation and calcium handling that vitamin K2 then directs into bone, complementing K2's role in mineralization.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Vitamin K2
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Magnesium supports the vitamin D activation and calcium handling that vitamin K2 then directs into bone, complementing K2's role in mineralization.
Mechanism. Magnesium is a required cofactor for the enzymes that hydroxylate vitamin D to its active form and for normal calcium regulation, while vitamin K2 carboxylates osteocalcin and matrix Gla protein to direct calcium into bone and away from soft tissue.
Recommendation. Can be taken together to support bone and cardiovascular calcium metabolism; both are commonly combined in bone-support stacks with no time separation needed.
Sources (2)
- Uwitonze AM and Razzaque MS, Role of Magnesium in Vitamin D Activation and Function, Journal of the American Osteopathic Association, 2018
- Maresz K, Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health, Integrative Medicine, 2015
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Vitamin K2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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