Supplement × Prescription·a synergy·Moderate evidence

Magnesium Glycinate + Ziprasidone

Synergy Moderate evidence

Low magnesium can increase torsades de pointes risk in patients taking QT-prolonging drugs such as ziprasidone.

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Pair type
Synergy
Evidence
Moderate
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyModerate evidence

What is happening. Low magnesium can increase torsades de pointes risk in patients taking QT-prolonging drugs such as ziprasidone.

Mechanism. Adequate magnesium supports cardiac repolarization stability and reduces arrhythmia vulnerability when QT is prolonged.

Recommendation. Correct magnesium deficiency under clinician guidance; do not use magnesium as a substitute for ECG or electrolyte monitoring in high-risk patients.

Stack Score

How it moves the number.

Effect on the composite score

If both Magnesium Glycinate and Ziprasidone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Pfizer Inc. GEODON US Prescribing Information. 2024.Needs sourceNo link

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