From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Melatonin can add to ziprasidone-related somnolence, dizziness, and impaired coordination.
Mechanism. Additive CNS depressant and sleep-promoting effects.
Recommendation. Use cautiously and avoid driving or hazardous tasks until individual effects are known.
Stack Score
How it moves the number.
Effect on the composite score
If both Melatonin and Ziprasidone are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Pfizer Inc. GEODON US Prescribing Information. 2024.Needs sourceNo link