NutriStack
MDMA and SAMe, a conflict.
SAMe has serotonergic and mood-elevating activity that can add to MDMA's serotonin release, increasing the risk of serotonin excess when the two are combined.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Conflict
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Conflict · Emerging evidence
Conflict
What is happening. SAMe has serotonergic and mood-elevating activity that can add to MDMA's serotonin release, increasing the risk of serotonin excess when the two are combined.
Mechanism. SAMe is a methyl donor that supports monoamine including serotonin metabolism and has been associated with serotonergic effects, which may add to the large serotonin release driven by MDMA.
Recommendation. Do not combine. Seek medical advice, and watch for agitation, sweating, tremor, or rapid heartbeat as signs of serotonin excess.
Stack Score
How this pair moves the number.
Effect on the composite score
If both MDMA and SAMe are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.