NutriStack
Alcohol and MDMA, a conflict.
Combining MDMA with alcohol increases dehydration, cardiovascular strain, and impaired judgment, and alcohol can mask MDMA's perceived effects while worsening next-day impairment and overheating risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Conflict
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Conflict · Moderate evidence
Conflict
What is happening. Combining MDMA with alcohol increases dehydration, cardiovascular strain, and impaired judgment, and alcohol can mask MDMA's perceived effects while worsening next-day impairment and overheating risk.
Mechanism. MDMA raises body temperature and cardiovascular workload and impairs thermoregulation, while alcohol promotes fluid loss and further impairs judgment, additively increasing the risk of dehydration, hyperthermia, and cardiac stress.
Recommendation. Do not combine. If overheating, confusion, chest pain, or collapse occurs, seek emergency medical care immediately.
Sources (2)
- Hernández-López C et al. 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics. J Pharmacol Exp Ther. 2002;300(1):236-44. PMID 11752122
- Liechti ME. Effects of MDMA on body temperature in humans. Temperature (Austin). 2014;1(3):192-200. PMID 27626046
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and MDMA are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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