NutriStack
Meloxicam and Nattokinase, a caution.
Nattokinase may add fibrinolytic effects to meloxicam's NSAID bleeding risk. Meloxicam can still cause GI injury with daily use, and nattokinase may make bleeding harder to stop. Risk is higher with prior ulcers, procedures, older age, or other blood-thinning medicines.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Meloxicam and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Nattokinase may add fibrinolytic effects to meloxicam's NSAID bleeding risk. Meloxicam can still cause GI injury with daily use, and nattokinase may make bleeding harder to stop. Risk is higher with prior ulcers, procedures, older age, or other blood-thinning medicines.
Mechanism. Nattokinase enhances fibrinolytic activity and can affect coagulation profiles. Meloxicam inhibits prostaglandin synthesis and can weaken GI mucosal defense, so clot-destabilizing effects may matter if bleeding starts.
Recommendation. Avoid nattokinase if you use meloxicam daily or have bleeding risk factors. Stop nattokinase before procedures unless your clinician specifically recommends continuing it.
Sources (2)
- Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
- Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010;24(2):121-132. PMID 20227026
Stack Score
How this pair moves the number.
Effect on the composite score
If both Meloxicam and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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