What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Fish Oil + Meloxicam pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Fish Oil and Meloxicam, a caution.

Q: Can I take Fish Oil and Meloxicam together?

Possibly, but with caution. Fish Oil and Meloxicam have a documented caution-tier interaction. High-dose fish oil may add mild antiplatelet activity to meloxicam's GI bleeding risk. Most randomized-trial data do not show major bleeding increases at usual omega-3 doses, but high-dose EPA/DHA and other bleeding risks can matter. The combination is more important with daily meloxicam, ulcer history, aspirin use, or planned procedures.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

High-dose fish oil may add mild antiplatelet activity to meloxicam's GI bleeding risk. Most randomized-trial data do not show major bleeding increases at usual omega-3 doses, but high-dose EPA/DHA and other bleeding risks can matter. The combination is more important with daily meloxicam, ulcer history, aspirin use, or planned procedures.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Fish Oil and Meloxicam
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. High-dose fish oil may add mild antiplatelet activity to meloxicam's GI bleeding risk. Most randomized-trial data do not show major bleeding increases at usual omega-3 doses, but high-dose EPA/DHA and other bleeding risks can matter. The combination is more important with daily meloxicam, ulcer history, aspirin use, or planned procedures.

Mechanism. EPA and DHA can reduce platelet aggregation and alter thromboxane balance. Meloxicam can impair gastric mucosal protection through prostaglandin suppression, allowing platelet effects to become clinically relevant if GI injury occurs.

Recommendation. Use caution with high-dose fish oil while taking meloxicam daily. Tell your clinician before procedures and monitor for black stools, vomiting blood, nosebleeds, or unusual bruising.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Fish Oil and Meloxicam are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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