NutriStack
Ginkgo Biloba and Meloxicam, a caution.
Ginkgo biloba may add bleeding risk to meloxicam. Meloxicam can still cause NSAID GI injury despite partial COX-2 selectivity, and ginkgo has case reports of spontaneous bleeding. Risk is higher with daily meloxicam, older age, ulcer history, or additional blood-thinning medicines.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ginkgo Biloba and Meloxicam
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Ginkgo biloba may add bleeding risk to meloxicam. Meloxicam can still cause NSAID GI injury despite partial COX-2 selectivity, and ginkgo has case reports of spontaneous bleeding. Risk is higher with daily meloxicam, older age, ulcer history, or additional blood-thinning medicines.
Mechanism. Ginkgo may inhibit platelet activation through platelet-activating factor pathways. Meloxicam inhibits prostaglandin synthesis and can weaken gastric mucosal defense, allowing antiplatelet effects to matter more clinically.
Recommendation. Avoid ginkgo if you use meloxicam every day or have a history of ulcers or bleeding. If both are used, watch for unusual bruising, nosebleeds, black stools, or severe headache.
Sources (2)
- Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy. 2011;31(5):490-502. PMID 21923430
- Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010;24(2):121-132. PMID 20227026
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ginkgo Biloba and Meloxicam are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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