What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Omeprazole + Saccharomyces Boulardii pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Omeprazole and Saccharomyces Boulardii, a synergy.

Q: Can I take Omeprazole and Saccharomyces Boulardii together?

Yes. The combination of Omeprazole and Saccharomyces Boulardii produces a measurable benefit. Saccharomyces boulardii is a non-pathogenic yeast probiotic with strong evidence for preventing antibiotic-associated and C. difficile-associated diarrhea, both of which are more common during omeprazole therapy. Meta-analyses support its use as adjunctive prophylaxis when PPIs are combined with antibiotics. Because it is a yeast, it is unaffected by antibacterial antibiotics.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Saccharomyces boulardii is a non-pathogenic yeast probiotic with strong evidence for preventing antibiotic-associated and C. difficile-associated diarrhea, both of which are more common during omeprazole therapy. Meta-analyses support its use as adjunctive prophylaxis when PPIs are combined with antibiotics. Because it is a yeast, it is unaffected by antibacterial antibiotics.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Omeprazole and Saccharomyces Boulardii
Pair type: Synergy
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Saccharomyces boulardii is a non-pathogenic yeast probiotic with strong evidence for preventing antibiotic-associated and C. difficile-associated diarrhea, both of which are more common during omeprazole therapy. Meta-analyses support its use as adjunctive prophylaxis when PPIs are combined with antibiotics. Because it is a yeast, it is unaffected by antibacterial antibiotics.

Mechanism. S. boulardii degrades C. difficile toxins A and B, competes for adhesion sites in the gut, and stimulates secretory IgA. Unlike bacterial probiotics, it survives concurrent antibiotic therapy.

Recommendation. If you take omeprazole and start a course of antibiotics, consider Saccharomyces boulardii 250-500 mg twice daily for the duration of the antibiotic and a few days after. Avoid in critically ill or severely immunocompromised patients due to rare fungemia risk.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Omeprazole and Saccharomyces Boulardii are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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