NutriStack
Pregabalin and Valerian Root, a caution.
Both pregabalin and valerian have sedating properties. Pregabalin binds alpha-2-delta calcium channel subunits; valerian modulates GABA-A. Combined sedation may cause excessive drowsiness.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Pregabalin and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both pregabalin and valerian have sedating properties. Pregabalin binds alpha-2-delta calcium channel subunits; valerian modulates GABA-A. Combined sedation may cause excessive drowsiness.
Mechanism. Pregabalin reduces excitatory neurotransmitter release via alpha-2-delta subunit binding. Valerian enhances GABAergic inhibition. Different CNS depressant mechanisms produce additive sedation.
Recommendation. If combining, use low valerian doses and monitor for excessive sedation, dizziness, and coordination problems.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Pregabalin and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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