Interaction databaseSupplement × SupplementReviewed May 2026

Psyllium Husk and Zinc, timing-sensitive.

Psyllium gel can bind zinc in the intestinal lumen, reducing the fraction of zinc absorbed when the two are taken at the same time.

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At a glance

Substances
Psyllium Husk and Zinc
Pair type
Timing Sensitive
Evidence (highest tier)
Moderate
Source citations
2 sources
Stack Score effect
−5 to your Stack Score (per scored timing-sensitive row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Timing Sensitive · Moderate evidence

Timing Sensitive

What is happening. Psyllium gel can bind zinc in the intestinal lumen, reducing the fraction of zinc absorbed when the two are taken at the same time.

Mechanism. The viscous soluble fiber matrix traps divalent zinc cations and limits mucosal contact while speeding transit, decreasing intestinal zinc uptake.

Recommendation. Separate zinc and psyllium by at least 2 hours. Take zinc with a light meal away from your fiber dose.

Minimum separation. 2 hours

Sources (2)
  1. Lonnerdal B, Dietary factors influencing zinc absorption, Journal of Nutrition, 2000. Dietary factors influencing zinc absorption. J Nutr. 2000. PMID 10801947
  2. Anderson JW et al, Health benefits of dietary fiber, Nutrition Reviews, 2009

Stack Score

How this pair moves the number.

Effect on the composite score

If both Psyllium Husk and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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