From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Vitamin C can improve non-heme iron absorption and may partly offset reduced iron solubility during acid suppression.
Mechanism. Ascorbic acid maintains iron in a more soluble reduced form.
Recommendation. Pair vitamin C with oral iron if tolerated, while monitoring objective iron response.
Stack Score
How it moves the number.
Effect on the composite score
If both Rabeprazole and Vitamin C are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Hutchinson C et al. Effect of omeprazole on iron absorption. Gut. 2007.Needs sourceNo link