Supplement × Prescription·timing-sensitive·Moderate evidence
Acid suppression may reduce absorption of calcium carbonate more than calcium citrate and long-term PPI therapy is associated with fracture risk.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Acid suppression may reduce absorption of calcium carbonate more than calcium citrate and long-term PPI therapy is associated with fracture risk.
Mechanism. Reduced gastric acidity can impair dissolution of acid-dependent calcium salts.
Recommendation. Use adequate calcium and vitamin D intake; calcium citrate may be preferred if acid suppression is continuous.
Effect on the composite score
If both Calcium and Rabeprazole are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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