Supplement × Prescription·contraindicated·Strong evidence
St. John's Wort is explicitly contraindicated with selegiline transdermal labeling and is unsafe with MAOI therapy because of serotonergic effects.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort is explicitly contraindicated with selegiline transdermal labeling and is unsafe with MAOI therapy because of serotonergic effects.
Mechanism. Serotonergic herb effects combine with MAO inhibition to increase serotonin syndrome risk.
Recommendation. Do not use St. John's Wort with selegiline.
Effect on the composite score
If both Selegiline and St. John's Wort are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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